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{UAH} African genomics: The scientists unlocking cures encoded in DNA

https://www.aljazeera.com/features/2021/1/1/african-genomics-the-scientists-unlocking-cures-encoded-in-dna?fbclid=IwAR3nSo8PNooPtqD2mfgrz_f2dX8HNNASdWlGXiBGabEKJYeTyKnk5f-Xjfo

Dr Ambroise Wonkam carries hundreds of thousands of years of history in his blood. The impacts of pathogens, migration, environment and geography are written into the braids of DNA he inherited from tens of thousands of generations of ancestors.

This richness, he remarks, is not unique. It is a shared legacy for more than one billion people: in South Africa, where he works; in Cameroon, where he is from; and across the African continent – the most genetically diverse landmass on earth. With such wealth all around him, how could he not spend his life studying it?

Wonkam is one of several scientists from Africa who made significant gains in 2020 towards understanding diseases that affect millions – and are not novel pandemic viruses. He and others lead large experiments that analyse whole genome data from thousands of African volunteers in South Africa, Ghana, Nigeria and beyond.

The knowledge these scientists are collecting is broadening humanity's reference genetic archive, the libraries scientists around the world use to identify and compare genomic information. It is filling in blind spots in a field that has been dominated for a generation by institutions in the Global North and in data that has historically not included African participants. Despite lockdowns and working from home, 2020 was a productive year for Wonkam and his peers.


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