Passing sentence, Judge Jeremy Richardson QC said the defendants "existed in a swamp of drug addiction and drug peddling" and Poppy was "plunged into mire of drugs".
"The life of Poppy can only be characterised as tragic from the moment she was conceived," he added.
The jury at Hull Crown Court heard Pyke, of Ladysmith Road, and Rytting, of Frederick Street, encouraged the girl to eat sedatives because they felt she was an inconvenience to their relationship.
Image copyrightHumberside PoliceImage caption John Rytting and Michala Pyke were found guilty of child cruelty last month
Text messages between the pair talked about Poppy having a "blue Smartie" - believed to be a reference to diazepam, and going to sleep, the court heard.
A post-mortem examination could not establish a cause of death, but toxicology tests found she had ingested significant amounts of heroin and methadone for a period of between two and six months before her death.
'Unbelievable vileness'
In a statement, Poppy's father Brendan Widdison said his daughter loved playing with animals and was "everything to us".
"Her bedroom remains untouched just as she left it with all her toys from her birthday that she never got chance to play with," he said.
"I agree that there was failings at different times in Poppy's life but none of this resulted in her death. This was down to two people [and their] despicable acts of unbelievable vileness."
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